Advertisement
American Society for Microbiology ("ASM") is committed to maintaining your confidence and trust with respect to the information we collect from you on websites owned and operated by ASM ("ASM Web Sites") and other sources. This Privacy Policy sets forth the information we collect about you, how we use this information and the choices you have about how we use such information.
FIND OUT MORE about the privacy policy
CLOSE
Advanced search
Suggested Terms:
BACK
mBio logo

mBio Latest Articles

Research Article

Genetics and Molecular BiologyResearch Article27 October 2022
FtsK, a DNA Motor Protein, Coordinates the Genome Segregation and Early Cell Division Processes in Deinococcus radiodurans
  • Shruti Mishra,
  • Hari S. Misra,
  • Swathi Kota
https://doi.org/10.1128/mbio.01742-22
Deinococcus radiodurans show extraordinary resistance to gamma radiation. It is polyploid and harbors a multipartite genome comprised of 2 chromosomes and 2 plasmids, packaged in a doughnut-shaped toroidal nucleoid.
Host-Microbial InteractionsResearch Article27 October 2022
Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner
  • Jianing Chen,
  • Ping Zeng,
  • Lan Gong,
  • Xujun Zhang,
  • Zongxin Ling,
  • Kefan Bi,
  • Fan Shi,
  • Kaihang Wang,
  • Qiong Zhang,
  • Jingjing Jiang,
  • Yanhui Zhang,
  • Toshimitsu Uede,
  • Emad M. El-Omar,
  • Hongyan Diao
https://doi.org/10.1128/mbio.02531-22
Gut microbiota are involved in metabolic disorders. However, microbiome-based therapeutic interventions are not always effective, which might be due to interference of the host factors.
VirologyResearch Article27 October 2022
Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans
  • Troy C. Sutton,
  • Elaine W. Lamirande,
  • Devanshi R. Patel,
  • Katherine E. E. Johnson,
  • Rita Czako,
  • Elodie Ghedin,
  • Raphael T. C. Lee,
  • Sebastian Maurer-Stroh,
  • Kanta Subbarao
https://doi.org/10.1128/mbio.02540-22
Airborne transmission in ferrets is used to gauge the pandemic potential of emerging influenza viruses; however, some emerging influenza viruses that transmit between ferrets do not spread between humans. Therefore, we evaluated sequential rounds of ...
Microbial GeneticsResearch Article27 October 2022
The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis
  • Emily Puumala,
  • Olga Zaslaver,
  • Amy Chen,
  • Dustin Duncan,
  • Meea Fogal,
  • Rebecca S. Shapiro,
  • Mohammad T. Mazhab-Jafari,
  • Luke Whitesell,
  • J. Rafael Montenegro-Burke,
  • Nicole Robbins,
  • Leah E. Cowen
https://doi.org/10.1128/mbio.02730-22
As widespread antimicrobial resistance threatens to propel the world into a postantibiotic era, there is a pressing need to identify mechanistically distinct antimicrobial agents. This is of particular concern when considering the limited arsenal of drugs ...
BacteriologyResearch Article26 October 2022
Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
  • Laura Reinhardt,
  • Dhana Thomy,
  • Markus Lakemeyer,
  • Linda Maria Westermann,
  • Joaquin Ortega,
  • Stephan A. Sieber,
  • Peter Sass,
  • Heike Brötz-Oesterhelt
https://doi.org/10.1128/mbio.01413-22
Clp proteases are antibiotic and anticancer drug targets. Composed of the proteolytic core ClpP and a regulatory Clp-ATPase, the protease machinery is important for protein homeostasis and regulatory proteolysis.
EvolutionResearch Article26 October 2022
Genome-Wide Association Studies across Environmental and Genetic Contexts Reveal Complex Genetic Architecture of Symbiotic Extended Phenotypes
  • Rebecca T. Batstone,
  • Hanna Lindgren,
  • Cassandra M. Allsup,
  • Laura A. Goralka,
  • Alex B. Riley,
  • Michael A. Grillo,
  • Amy Marshall-Colon,
  • Katy D. Heath
https://doi.org/10.1128/mbio.01823-22
Given the rapid rise of research on how microbiomes can be harnessed to improve host health, understanding the contribution of microbial genetic variation to host phenotypic variation is pressing, and will better enable us to predict the evolution of (and ...
EpidemiologyResearch Article26 October 2022
Identifying Recent Cholera Infections Using a Multiplex Bead Serological Assay
  • Forrest K. Jones,
  • Taufiqur R. Bhuiyan,
  • Rachel E. Muise,
  • Ashraful I. Khan,
  • Damien M. Slater,
  • Kian Robert Hutt Vater,
  • Fahima Chowdhury,
  • Meagan Kelly,
  • Peng Xu,
  • Pavol Kováč,
  • Rajib Biswas,
  • Mohammad Kamruzzaman,
  • Edward T. Ryan,
  • Stephen B. Calderwood,
  • Regina C. LaRocque,
  • Justin Lessler,
  • Richelle C. Charles,
  • Daniel T. Leung,
  • Firdausi Qadri,
  • Jason B. Harris,
  • Andrew S. Azman
https://doi.org/10.1128/mbio.01900-22
Reliable estimates of cholera incidence are challenged by poor clinical surveillance and health-seeking behavior biases. We showed that cross-sectional serologic profiles measured with a high-throughput multiplex bead assay can lead to accurate ...

Commentary

BacteriologyCommentary26 October 2022
The Remarkable Genetics of Helicobacter pylori
  • Daniel Falush
https://doi.org/10.1128/mbio.02158-22
The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F.

Research Article

Antimicrobial ChemotherapyResearch Article26 October 2022
Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus
  • Norman van Rhijn,
  • Sam Hemmings,
  • Isabelle S. R. Storer,
  • Clara Valero,
  • Hajer Bin Shuraym,
  • Gustavo H. Goldman,
  • Fabio Gsaller,
  • Jorge Amich,
  • Michael J. Bromley
https://doi.org/10.1128/mbio.02215-22
Aspergillosis is a spectrum of diseases and a major cause of morbidity and mortality. To treat these diseases, there are a few classes of antifungal drugs approved for clinical use.

Commentary

Pathogenesis and Host ResponseCommentary26 October 2022
The Glymphatic System: a Potential Key Player in Bacterial Meningitis
  • Marco Rinaldo Oggioni,
  • Uwe Koedel
https://doi.org/10.1128/mbio.02350-22
The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several ...

Research Article

Host-Microbial InteractionsResearch Article26 October 2022
The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN
  • Lillian F. Zhang,
  • Bernd Lepenies,
  • Sayuri Nakamae,
  • Briana M. Young,
  • Renato L. Santos,
  • Manuela Raffatellu,
  • Brian A. Cobb,
  • Hirotaka Hiyoshi,
  • Andreas J. Bäumler
https://doi.org/10.1128/mbio.02733-22
Salmonella enterica subspecies enterica serovar Typhi is the causative agent of typhoid fever. The recent emergence of S. Typhi strains which are resistant to antibiotic therapy highlights the importance of vaccination in managing typhoid fever.
Genomics and ProteomicsResearch Article20 October 2022
Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families
  • João Luís Reis-Cunha,
  • Anderson Coqueiro-dos-Santos,
  • Samuel Alexandre Pimenta-Carvalho,
  • Larissa Pinheiro Marques,
  • Gabriela F. Rodrigues-Luiz,
  • Rodrigo P. Baptista,
  • Laila Viana de Almeida,
  • Nathan Ravi Medeiros Honorato,
  • Francisco Pereira Lobo,
  • Vanessa Gomes Fraga,
  • Lucia Maria da Cunha Galvão,
  • Lilian Lacerda Bueno,
  • Ricardo Toshio Fujiwara,
  • Mariana Santos Cardoso,
  • Gustavo Coutinho Cerqueira,
  • Daniella C. Bartholomeu
https://doi.org/10.1128/mbio.02319-22
Sequences that have several copies in a genome, such as multicopy-gene families, mobile elements, and microsatellites, are among the most challenging genomic segments to study. They are frequently underestimated in genome assemblies, hampering the correct ...
Genetics and Molecular BiologyResearch Article20 October 2022
RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS–StpA Nucleoprotein Filaments in Pathogenic Escherichia coli
  • Christine M. Hustmyer,
  • Michael B. Wolfe,
  • Rodney A. Welch,
  • Robert Landick
https://doi.org/10.1128/mbio.02662-22
Bacterial pathogens adapt to hosts and host defenses by reprogramming gene expression, including by H-NS counter-silencing. Counter-silencing turns on transcription initiation when regulators bind to promoters and rearrange repressive H-NS nucleoprotein ...

Guest Editorial

Editorial20 October 2022
COP27 Climate Change Conference: Urgent Action Needed for Africa and the World
  • Lukoye Atwoli,
  • Gregory E. Erhabor,
  • Aiah A. Gbakima,
  • Abraham Haileamlak,
  • Jean-Marie Kayembe Ntumba,
  • James Kigera,
  • Laurie Laybourn-Langton,
  • Bob Mash,
  • Joy Muhia,
  • Fhumulani Mavis Mulaudzi,
  • David Ofori-Adjei,
  • Friday Okonofua,
  • Arash Rashidian,
  • Maha El-Adawy,
  • Siaka Sidibé,
  • Abdelmadjid Snouber,
  • James Tumwine,
  • Mohammad Sahar Yassien,
  • Paul Yonga,
  • Lilia Zakhama,
  • Chris Zielinski
https://doi.org/10.1128/mbio.02722-22
Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change

Minireview

Systems BiologyMinireview19 October 2022
Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses
  • Madison R. Spratt,
  • Keara Lane
https://doi.org/10.1128/mbio.02212-22
The ability of bacteria to respond to changes in their environment is critical to their survival, allowing them to withstand stress, form complex communities, and induce virulence responses during host infection. A remarkable feature of many of these ...

Research Article

Microbial PathogenesisResearch Article19 October 2022
Genome-Wide Analysis of AGC Kinases Reveals that MoFpk1 Is Required for Development, Lipid Metabolism, and Autophagy in Hyperosmotic Stress of the Rice Blast Fungus Magnaporthe oryzae
  • Ming-Hua Wu,
  • Qin Yu,
  • Tian-Yi Tao,
  • Li-Xiao Sun,
  • Hui Qian,
  • Xue-Ming Zhu,
  • Lin Li,
  • Shuang Liang,
  • Jian-Ping Lu,
  • Fu-Cheng Lin,
  • Xiao-Hong Liu
https://doi.org/10.1128/mbio.02279-22
Our identification and analysis of evolutionary and biological relationships provide us with an unprecedented high-resolution view of the flexible and conserved roles of the AGC family in the topmost fungal pathogens that infect rice, wheat, barley, and ...
Microbial EcologyResearch Article19 October 2022
Structural and Genomic Evolution of RRNPPA Systems and Their Pheromone Signaling
  • Alonso Felipe-Ruiz,
  • Alberto Marina,
  • Eduardo P. C. Rocha
https://doi.org/10.1128/mbio.02514-22
Quorum sensing (QS) is a mechanism of bacterial communication, coordinating important decisions depending on bacterial population. QS regulates important processes not only in bacterial behavior but also in genetic mobile elements and host-guest ...
VirologyResearch Article18 October 2022
Casirivimab and Imdevimab Treatment Reduces Viral Load and Improves Clinical Outcomes in Seropositive Hospitalized COVID-19 Patients with Nonneutralizing or Borderline Neutralizing Antibodies
  • Andrea T. Hooper,
  • Selin Somersan-Karakaya,
  • Shane E. McCarthy,
  • Eleftherios Mylonakis,
  • Shazia Ali,
  • Jingning Mei,
  • Rafia Bhore,
  • Adnan Mahmood,
  • Gregory P. Geba,
  • Paula Dakin,
  • David M. Weinreich,
  • George D. Yancopoulos,
  • Gary A. Herman,
  • Jennifer D. Hamilton
    • on behalf of for the COVID-19 Phase 2/3 Hospitalized Trial Team
https://doi.org/10.1128/mbio.01699-22
The clinical benefit of CAS+IMD in hospitalized seronegative patients with COVID-19 has previously been demonstrated, although these studies observed no clinical benefit in seropositive patients. As the prevalence of SARS-CoV-2-seropositive individuals ...
Molecular and Cellular BiologyResearch Article18 October 2022
HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit
  • Om Basukala,
  • Oscar Trejo-Cerro,
  • Michael P. Myers,
  • David Pim,
  • Paola Massimi,
  • Miranda Thomas,
  • Corrado Guarnaccia,
  • David Owen,
  • Lawrence Banks
https://doi.org/10.1128/mbio.02302-22
Despite being a very small protein, HPV-E7 has a wide range of functions within the infected cell, many of which can lead to cell transformation. High-risk HPV-E7 deregulates the function of many cellular proteins, perturbing cellular homeostasis.

Commentary

MycologyCommentary18 October 2022
A Fungal Sterylglucosidase at the Intersection of Virulence, Host Immunity, and Therapeutic Development
  • Robert A. Cramer
https://doi.org/10.1128/mbio.02425-22
Human fungal infections (mycoses) cause significant morbidity and mortality in high-risk populations. Contemporary antifungal therapies rely heavily on three classes of antifungal drugs, and to date, no fungal vaccine is in clinical use for invasive ...

Research Article

VirologyResearch Article18 October 2022
Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection
  • Tate Tabtieng,
  • Rachel C. Lent,
  • Machika Kaku,
  • Alvaro Monago Sanchez,
  • Marta Maria Gaglia
https://doi.org/10.1128/mbio.02446-22
Type I interferons are key factors that dictate the outcome of infectious and inflammatory diseases. Thus, intricate cellular regulatory mechanisms are in place to control IFN responses.
Genetics and Molecular BiologyResearch Article13 October 2022
Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli
  • Teppei Morita,
  • Nadim Majdalani,
  • Masahiro C. Miura,
  • Rerina Inose,
  • Taku Oshima,
  • Masaru Tomita,
  • Akio Kanai,
  • Susan Gottesman
https://doi.org/10.1128/mbio.02371-22
Growing evidence suggests that the modulation of intrinsic termination and readthrough of transcription is more widespread than previously appreciated. For small RNAs, proper termination plays a critical role in their regulatory function.
Microbial EcologyResearch Article12 October 2022
Single Seed Microbiota: Assembly and Transmission from Parent Plant to Seedling
  • Guillaume Chesneau,
  • Béatrice Laroche,
  • Anne Préveaux,
  • Coralie Marais,
  • Martial Briand,
  • Brice Marolleau,
  • Marie Simonin,
  • Matthieu Barret
https://doi.org/10.1128/mbio.01648-22
Seeds are key components of plant fitness and are central to the sustainability of the agri-food system. Both the seed quality for food consumption and the seed vigor in agricultural settings can be influenced by the seed microbiota.
Host-Microbial InteractionsResearch Article12 October 2022
Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis
  • Cooper Alastair Grace,
  • Kátia Silene Sousa Carvalho,
  • Mayara Ingrid Sousa Lima,
  • Vladimir Costa Silva,
  • João Luís Reis-Cunha,
  • Matthew J. Brune,
  • Sarah Forrester,
  • Conceição de Maria Pedrozo e Silva de Azevedo,
  • Dorcas Lamounier Costa,
  • Doug Speed,
  • Jeremy C. Mottram,
  • Daniel C. Jeffares,
  • Carlos H. N. Costa
https://doi.org/10.1128/mbio.02068-22
Multiple factors contribute to the risk of mortality from visceral leishmaniasis (VL), including, patient genotype, comorbidities, and nutrition. Many of these factors are influenced by socioeconomic biases.
Antimicrobial ChemotherapyResearch Article12 October 2022
Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis
  • Charles D. Giamberardino,
  • Wiley A. Schell,
  • Jennifer L. Tenor,
  • Dena L. Toffaletti,
  • Julia R. Palmucci,
  • Choiselle Marius,
  • Jane-Valeriane K. Boua,
  • Quinlyn Soltow,
  • Robert Mansbach,
  • M. Arthur Moseley,
  • J. Will Thompson,
  • Laura G. Dubois,
  • William Hope,
  • John R. Perfect,
  • Karen Joy Shaw
https://doi.org/10.1128/mbio.02347-22
Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. The gepix Gwt1 inhibitors are a new class of antifungal drugs.
Host-Microbial InteractionsResearch Article12 October 2022
Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling
  • Hamlet Acevedo Ospina,
  • Marie-Michèle Guay-Vincent,
  • Albert Descoteaux
https://doi.org/10.1128/mbio.02578-22
To colonize host phagocytes, Leishmania metacyclic promastigotes subvert host defense mechanisms and create a specialized intracellular niche adapted to their replication. This is accomplished through the action of virulence factors, including the surface ...
MycologyResearch Article11 October 2022
Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation
  • Leandro José de Assis,
  • Judith M. Bain,
  • Corin Liddle,
  • Ian Leaves,
  • Christian Hacker,
  • Roberta Peres da Silva,
  • Raif Yuecel,
  • Attila Bebes,
  • David Stead,
  • Delma S. Childers,
  • Arnab Pradhan,
  • Kevin Mackenzie,
  • Katherine Lagree,
  • Daniel E. Larcombe,
  • Qinxi Ma,
  • Gabriela Mol Avelar,
  • Mihai G. Netea,
  • Lars P. Erwig,
  • Aaron P. Mitchell,
  • Gordon D. Brown,
  • Neil A. R. Gow,
  • Alistair J. P. Brown
https://doi.org/10.1128/mbio.02605-22
Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign” and used to ...
BacteriologyResearch Article11 October 2022
Metabolic Mechanism and Physiological Role of Glycerol 3-Phosphate in Pseudomonas aeruginosa PAO1
  • Yidong Liu,
  • Wenxuan Sun,
  • Liting Ma,
  • Rong Xu,
  • Chunyu Yang,
  • Ping Xu,
  • Cuiqing Ma,
  • Chao Gao
https://doi.org/10.1128/mbio.02624-22
In view of the intrinsic resistance of Pseudomonas aeruginosa to antibiotics and its potential to acquire resistance to current antibiotics, there is an urgent need to develop novel therapeutic options for the treatment of infections caused by this ...
BacteriologyResearch Article10 October 2022
GTP-Bound Escherichia coli FtsZ Filaments Are Composed of Tense Monomers: a Dynamic Nuclear Polarization-Nuclear Magnetic Resonance Study Using Interface Detection
  • Kelsey M. McCoy,
  • Keith J. Fritzsching,
  • Ann E. McDermott
https://doi.org/10.1128/mbio.02358-22
Bacterial replication is dependent on the cytoskeletal protein FtsZ, which forms filaments that scaffold and recruit other essential division proteins. While the FtsZ monomer is well studied across organisms, many questions remain about how the filaments ...
ImmunologyResearch Article10 October 2022
Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti-Toxoplasma Immunity
  • Zhiqiang Hu,
  • Dan Wu,
  • Jiansen Lu,
  • Yufen Zhang,
  • Shao-Meng Yu,
  • Yingchao Xie,
  • Hongyu Li,
  • Jianwu Yang,
  • De-Hua Lai,
  • Ke Zeng,
  • Huaji Jiang,
  • Zhao-Rong Lun,
  • Xiao Yu
https://doi.org/10.1128/mbio.02361-22
As a key component of innate immunity, inflammasome is critical for host antitoxoplasmosis immunity, but the underlying mechanisms are still elusive. In this study, we found that inflammasome signaling was activated by PAMPs of T. gondii, which generated ...
EcologyResearch Article10 October 2022
Wolbachia-Driven Memory Loss in a Parasitic Wasp Increases Superparasitism to Enhance Horizontal Transmission
  • Jin-Cheng Zhou,
  • Xu Zhao,
  • Liang-Xiao Huo,
  • Dan Shang,
  • Hui Dong,
  • Li-Sheng Zhang
https://doi.org/10.1128/mbio.02362-22
The endosymbiotic bacteria, Wolbachia, live widely within cells of arthropods. Wolbachia are not only transmitted vertically from host mother to offspring, but are also transmitted horizontally among host individuals. Horizontal transmission is expected ...
Human MicrobiomeResearch Article10 October 2022
Genome-Centric Dynamics Shape the Diversity of Oral Bacterial Populations
  • Daniel R. Utter,
  • Colleen M. Cavanaugh,
  • Gary G. Borisy
https://doi.org/10.1128/mbio.02414-22
The oral microbiome represents a microbial community of critical relevance to human health. Recent studies have documented the diversity and dynamics of different bacteria to reveal a rich, stable ecosystem characterized by strain-level dynamics.
Plant MicrobiologyResearch Article10 October 2022
Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems
  • Miguel A. Matilla,
  • Rita E. Monson,
  • Annabel Murphy,
  • Muriel Schicketanz,
  • Alison Rawlinson,
  • Caia Duncan,
  • Juan Mata,
  • Finian Leeper,
  • George P. C. Salmond
https://doi.org/10.1128/mbio.02472-22
Fungal infections represent a major clinical, agricultural, and food security threat worldwide, which is accentuated due to the difficult treatment of these infections. Microorganisms represent a prolific source of antibiotics, and current data support ...
VirologyResearch Article10 October 2022
Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection
  • Wanying Zhang,
  • Mo Zhou,
  • Cancan Chen,
  • Shiyu Wu,
  • Lilin Wang,
  • Baijin Xia,
  • Jun Liu,
  • Xiancai Ma,
  • Ting Pan,
  • Hui Zhang,
  • Linghua Li,
  • Bingfeng Liu
https://doi.org/10.1128/mbio.02496-22
Identification of cellular biomarkers is the crucial challenge to eradicate the HIV-1 latent reservoir. In our study, we identified CD98 as a novel plasma membrane biomarker for HIV-1 permissiveness and latent infection.
homepage mBio cover image
Advertisement