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Volume 7Issue 5October 2022

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EDITOR IN CHIEF: Dr. Jack A. Gilbert

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Editor in Chief

Dr. Jack A. Gilbert

Editor in Chief (2025) | University of California San Diego

Jack A. Gilbert is a Professor in Pediatrics and the Scripps Institution of Oceanography. Dr. Gilbert uses molecular tools to test fundamental hypotheses in microbial ecology. He cofounded the Earth Microbiome Project and has authored more than 350 peer-reviewed publications and book chapters on microbial ecology.

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Dr. Thomas J. Silhavy

Editor in Chief (2021) | Princeton University

Thomas J. Silhavy is the Warner-Lambert Parke-Davis Professor of Molecular Biology at Princeton University. He is a bacterial geneticist who has made fundamental contributions to several different research fields.

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mSystems Author Videos

Multiscale Spatiotemporal Model Reproduces Succession in the Early Infant Gut Microbiota

September 7, 2022
The composition of the infant microbiota has a great impact on infant health, but its controlling factors are still incompletely understood. The frequently dominant anaerobic Bifidobacterium species benefit health, e.g., they can keep harmful competitors under control and modulate the intestinal immune response. Controlling factors could include nutritional composition and intestinal mucus composition, as well as environmental factors, such as antibiotics. We introduce a modeling framework of a metabolically realistic intestinal microbial ecology in which hypothetical scenarios can be tested and compared. We present simulations that suggest that greater levels of intraintestinal oxygenation more strongly delay the dominance of Bifidobacterium species, explaining the observed variety of microbial composition and demonstrating the use of the model for hypothesis generation. The framework allowed us to test a variety of controlling factors, including intestinal mixing and transit time. Future versions will also include detailed modeling of oligosaccharide and mucin metabolism.

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Pandemic Built Environment

April 6, 2021

During the pandemic researchers who focus on the microbiology of built environments suddenly found themselves at the center of attention.
Understanding how SARS-CoV-2 may be spreading indoors became incredibly important to ensure we can operate indoors in a safe manner.
We now know that SARS-CoV-2 transmits through the air in droplets and as particles, and this information has helped us to provide comprehensive advice on how people should manage the indoor environment.
Last year my guests published a review in mSystems: 2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission. This is published with co-authors David A. Coil, Mark Fretz, and Jonathan A. Eisen. This paper was the most downloaded article for mSystems in 2020, and was in the top ten most downloaded articles across all ASM journals. This is maybe not surprising based on the topic covered.

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