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Research Article
1 May 1990

Sucralfate significantly reduces ciprofloxacin concentrations in serum

Abstract

The effect of sucralfate on the bioavailability of ciprofloxacin was evaluated in eight healthy subjects utilizing a randomized, crossover design. The area under the concentration-time curve from 0 to 12 h was reduced from 8.8 to 1.1 micrograms.h/ml by sucralfate (P less than 0.005). Similarly, the maximum concentration of ciprofloxacin in serum was reduced from 2.0 to 0.2 micrograms/ml (P less than 0.005). We conclude that concurrent ingestion of sucralfate significantly reduces the concentrations in serum produced by a 500-mg dose of ciprofloxacin. On the basis of these findings, ciprofloxacin and sucralfate should not be administered concurrently.

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Published In

cover image Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Volume 34Number 5May 1990
Pages: 931 - 933
PubMed: 2360833

History

Published online: 1 May 1990

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Contributors

Authors

J C Garrelts
Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.
P J Godley
Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.
J D Peterie
Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.
E H Gerlach
Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.
C C Yakshe
Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.

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