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Research Article
1 December 1988

Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri

Abstract

Lactobacillus reuteri is a prominent member of the Lactobacillus population in the gastrointestinal ecosystem of humans, poultry, swine, and other animals. Reuterin is a newly discovered, broad-spectrum antimicrobial substance produced by this species during fermentation of glycerol. In this report, we describe procedures for (i) producing reuterin in sufficient amounts to isolate from a fermentation mixture and (ii) isolating this substance by high-performance liquid chromatography. By using uniformly labeled [14C]glycerol, reuterin was identified as a product of glycerol fermentation associated with the production of beta-hydroxypropionic acid and trimethylene glycol.

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Published In

cover image Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Volume 32Number 12December 1988
Pages: 1854 - 1858
PubMed: 3245697

History

Published online: 1 December 1988

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Contributors

Authors

T L Talarico
Department of Microbiology, North Carolina State University, Raleigh 27695.
I A Casas
Department of Microbiology, North Carolina State University, Raleigh 27695.
T C Chung
Department of Microbiology, North Carolina State University, Raleigh 27695.
W J Dobrogosz
Department of Microbiology, North Carolina State University, Raleigh 27695.

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