Mutation frequency of Haemophilus influenzae to rifampin resistance
Abstract
Twenty-two susceptible strains of Haemophilus influenzae were examined for mutation to rifampin resistance (minimal inhibitory concentration, greater than or equal to 10 micrograms/ml). All strains had detectable apparent mutation frequencies with a median minimal inhibitory concentration 2,000-fold greater than that of their wild-type parents. Of the type b strain mutants, 80% (8 of 10) expressed high-level resistance (minimal inhibitory concentration, 750 micrograms/ml) that was 75-fold greater than readily achievable serum concentrations.
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Information & Contributors
Information
Published In
Antimicrobial Agents and Chemotherapy
Volume 22 • Number 3 • September 1982
Pages: 531 - 533
PubMed: 6982682
History
Published online: 1 September 1982
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Citations
Citation
1982.
Mutation frequency of Haemophilus influenzae to rifampin resistance. Antimicrob Agents Chemother
22:.
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