Advertisement
Free access
Research Article
1 September 1994

The alphaviruses: gene expression, replication, and evolution

Abstract

The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses. The complete sequences of the +/- 11.7-kb plus-strand RNA genomes of eight alphaviruses have been determined, and partial sequences are known for several others; this has made possible evolutionary comparisons between different alphaviruses as well as comparisons of this group of viruses with other animal and plant viruses. Full-length cDNA clones from which infectious RNA can be recovered have been constructed for four alphaviruses; these clones have facilitated many molecular genetic studies as well as the development of these viruses as expression vectors. From these and studies involving biochemical approaches, many details of the replication cycle of the alphaviruses are known. The interactions of the viruses with host cells and host organisms have been exclusively studied, and the molecular basis of virulence and recovery from viral infection have been addressed in a large number of recent papers. The structure of the viruses has been determined to about 2.5 nm, making them the best-characterized enveloped virus to date. Because of the wealth of data that has appeared, these viruses represent a well-characterized system that tell us much about the evolution of RNA viruses, their replication, and their interactions with their hosts. This review summarizes our current knowledge of this group of viruses.

Formats available

You can view the full content in the following formats:

Information & Contributors

Information

Published In

cover image Microbiological Reviews
Microbiological Reviews
Volume 58Number 3September 1994
Pages: 491 - 562
PubMed: 7968923

History

Published online: 1 September 1994

Permissions

Request permissions for this article.

Contributors

Authors

J H Strauss
Division of Biology, California Institute of Technology, Pasadena 91125.
E G Strauss
Division of Biology, California Institute of Technology, Pasadena 91125.

Metrics & Citations

Metrics

VIEW ALL METRICS

Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

View Options

View options

PDF/ePub

PDF/ePub

Get Access

LOGIN OPTIONS
Non-Member Login
Buy Article
Microbiological Reviews Vol.58 • Issue 3 • ASM Journals Pay Per View, PPV 25
Journal Subscription
Microbiological Reviews
ASM members can purchase subscriptions to journals.
Join or renew

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

Figures and Media

Figures

Media

Tables

Share

Share

Share the article link

Share with email

Email a colleague

Share on social media

American Society for Microbiology ("ASM") is committed to maintaining your confidence and trust with respect to the information we collect from you on websites owned and operated by ASM ("ASM Web Sites") and other sources. This Privacy Policy sets forth the information we collect about you, how we use this information and the choices you have about how we use such information.
FIND OUT MORE about the privacy policy