Advances in the cellular biology, biochemistry, and molecular biology of acidocalcisomes
SUMMARY
Acidocalcisomes are organelles conserved during evolution and closely related to the so-called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of yeasts, and to the lysosome-related organelles of animal species. All these organelles have in common their acidity and high content of polyphosphate and calcium. They are characterized by a variety of functions from storage of phosphorus and calcium to roles in Ca2+ signaling, osmoregulation, blood coagulation, and inflammation. They interact with other organelles through membrane contact sites or by fusion, and have several enzymes, pumps, transporters, and channels.
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Author Bios
Department of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA
Roberto Docampo received an MD in 1972 from the University of Buenos Aires, a PhD in Microbiology in 1977 from the Federal University of Rio de Janeiro (UFRJ), and a PhD in Biological Chemistry in 1979 from the University of Buenos Aires. He then spent four years as a Visiting Scientist at the NIH before joining first, the UFRJ, and then the Rockefeller University, as Visiting Professor. He joined the University of Illinois at Urbana-Champaign in 1990 and in 2005 he moved to the University of Georgia where he remains as Distinguished Research Professor of Cellular Biology and Eminent Scholar. Docampo is best known for his work on the discovery and characterization of acidocalcisomes of different species. His lab was the first to determine the presence and secretion of polyphosphate by human platelets, which led to the discovery of its role in blood clotting. Docampo is Fellow of the American Academy of Microbiology and of the American Association for the Advancement of Science.
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Microbiology and Molecular Biology Reviews
Volume 88 • Number 1 • 27 March 2024
eLocator: e00042-23
Editor: Corrella S. Detweiler, University of Colorado Boulder, Boulder, Colorado, USA
PubMed: 38099688
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© 2023 American Society for Microbiology. All Rights Reserved.
History
Published online: 15 December 2023
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Corrella S. Detweiler
Editor
University of Colorado Boulder, Boulder, Colorado, USA
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Citations
Citation
2024.
Advances in the cellular biology, biochemistry, and molecular biology of acidocalcisomes. Microbiol Mol Biol Rev
88:e00042-23.
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