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Research Article
1 July 1994

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

Abstract

Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and Env were detected at or within 3 weeks of presentation in four of the five patients and were detected in all five patients by 3 to 6 months after presentation. The one patient with an absent initial CTL response had prolonged symptoms, persistent viremia, and low CD4+ T-cell count. Neutralizing antibody activity was absent at the time of presentation in all five patients. These findings suggest that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and indicate a role for CTL in protective immunity to HIV-1 in vivo.

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Published In

cover image Journal of Virology
Journal of Virology
Volume 68Number 7July 1994
Pages: 4650 - 4655
PubMed: 8207839

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Published online: 1 July 1994

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Authors

R A Koup
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
J T Safrit
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
Y Cao
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
C A Andrews
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
G McLeod
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
W Borkowsky
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
C Farthing
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
D D Ho
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.

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