Research Article
1 November 1994

Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10

Abstract

Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells.

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Published In

cover image Journal of Virology
Journal of Virology
Volume 68Number 11November 1994
Pages: 7575 - 7581
PubMed: 7933145

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Published online: 1 November 1994

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Authors

N Baumgarth
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
L Brown
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
D Jackson
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
A Kelso
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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