In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic
Abstract
The in vitro activity of decaplanin (formerly M86-1410), a novel glycopeptide antimicrobial agent, was tested against 169 gram-positive bloodstream isolates from patients at the University of Iowa Hospitals and Clinics and 12 selected vancomycin-resistant strains. Enterococcus faecalis, E. faecium, Staphylococcus aureus, streptococci, bacilli, corynebacteria, and listeria were inhibited by decaplanin (MICs for 90% of the strains tested [MIC90s], 0.12 to 4 micrograms/ml). However, some rarely isolated and selected Enterococcus sp. populations had a MIC90 of 16 micrograms/ml, and S. haemolyticus strains had a MIC90 of 8 micrograms/ml. These in vitro results suggest that decaplanin may be useful against most gram-positive strains, even though some Enterococcus species and coagulase-negative staphylococci were potentially resistant (MICs, greater than or equal to 8 micrograms/ml).
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Information & Contributors
Information
Published In
Antimicrobial Agents and Chemotherapy
Volume 36 • Number 4 • April 1992
Pages: 873 - 875
PubMed: 1386973
History
Published online: 1 April 1992
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Citation
1992.
In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic. Antimicrob Agents Chemother
36:.
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