Research Article
1 July 1981

Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa

Abstract

The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A against one strain of P. aeruginosa. Addition of a sublethal concentration of carbenicillin resulted in a significant increase in the rate of bacterial killing of FTM-A against P. aeruginosa. The antibacterial activity of FTM-A against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of P. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin.

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cover image Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Volume 20Number 1July 1981
Pages: 33 - 37
PubMed: 6792980

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Published online: 1 July 1981

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