ABSTRACT

We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France between 2004 and 2020. Nine of 1,715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne mef(C)-mph(G) gene combination, described here for the first time for E. coli. Azithromycin resistance, although rare, needs consideration, as this treatment may be useful in cases of STEC infection.

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Information & Contributors

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Published In

cover image Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Volume 66Number 215 February 2022
eLocator: e01949-21
PubMed: 34871091

History

Received: 3 October 2021
Returned for modification: 27 October 2021
Accepted: 26 November 2021
Accepted manuscript posted online: 6 December 2021
Published online: 15 February 2022

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KEYWORDS

  1. EHEC
  2. azithromycin resistance
  3. fosfomycin
  4. macrolide resistance
  5. macrolides
  6. mef(C)-mph(G)
  7. mph(A)
  8. mph(B)
  9. phosphorylases
  10. rifaximin

Contributors

Authors

Etienne Bizot
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Aurélie Cointe
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Philippe Bidet
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Patricia Mariani-Kurkdjian
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Claire Amaris Hobson
Université de Paris, IAME, INSERM, Paris, France
Céline Courroux
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Sandrine Liguori
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Mélanie Magnan
Université de Paris, IAME, INSERM, Paris, France
Manel Merimèche
Université de Paris, IAME, INSERM, Paris, France
Service de Microbiologie, AP-HP, Hôpital Saint-Louis, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Service de Microbiologie, AP-HP, Hôpital Saint-Louis, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Service de Microbiologie, AP-HP, Hôpital Saint-Louis, Paris, France
François-Xavier Weill
Institut Pasteur, Unité des bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Paris, France
Sophie Lefèvre
Institut Pasteur, Unité des bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Paris, France
Stéphane Bonacorsi
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Université de Paris, IAME, INSERM, Paris, France
Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France
Université de Paris, IAME, INSERM, Paris, France

Notes

Etienne Bizot and Aurélie Cointe contributed equally to this work; author order is alphabetical.
The authors declare no conflict of interest.

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