Advertisement
Research Article
01 February 2021

Efficacy of ciprofloxacin for treatment of Brucella melitensis infections

Abstract

The effectiveness of treatment of human brucellosis caused by Brucella melitensis with ciprofloxacin alone was investigated in a prospective nonrandomized study. Subjects with central nervous system involvement, endocarditis, or severe renal dysfunction; children under 16 years of age; and pregnant women were excluded from the study. Of 19 patients, 16 completed the study; 7 were diagnosed as having acute systemic brucellosis, and 9 had acute brucella arthritis-diskitis. A rapid response to ciprofloxacin was seen in all 16 patients, but the blood cultures of 1 patient remained positive and the treatment was changed. During a 104-week follow-up period, 4 of the 15 responding patients relapsed or were reinfected within 8 to 32 weeks after completion of therapy. We conclude that treatment with ciprofloxacin alone, although effective for the acute symptoms, is associated with an appreciable rate of relapse; therefore, it should be given with other agents for treatment of brucellosis.
Formats available

You can view this article in different formats.

Information & Contributors

Information

Published In

Antimicrobial Agents and Chemotherapy cover image
Antimicrobial Agents and Chemotherapy
Volume 36Number 1January 1992
Pages: 150 - 152
PubMed: 1590681

History

Published online: 1 February 2021

Permissions

Request permissions for this article.

Contributors

Authors

M B al-Sibai
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M A Halim
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M M el-Shaker
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
B A Khan
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
S M Qadri
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Metrics & Citations

Metrics

Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

View Options

View options

PDF

Download PDF

Get Access

LOGIN OPTIONS
Non-Member Login
Buy Article
Antimicrobial Agents and Chemotherapy Vol.36 • Issue 1 • ASM Journals Pay Per View, PPV 25
Buy Article
Antimicrobial Agents and Chemotherapy Vol.36 • Issue 1 • ASM Journals Pay Per View, PPV 25
Journal Subscription
Antimicrobial Agents and Chemotherapy
ASM members can purchase subscriptions to journals.
Join or renew

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

Figures and Media

Figures

Media

Tables

Share

Share

Share the article link

Share with email

Share on social media

American Society for Microbiology ("ASM") is committed to maintaining your confidence and trust with respect to the information we collect from you on websites owned and operated by ASM ("ASM Web Sites") and other sources. This Privacy Policy sets forth the information we collect about you, how we use this information and the choices you have about how we use such information.
FIND OUT MORE about the privacy policy